Allylestrenol

Chemical Name: 17α-allylestr-4-en-17β-ol
Molecular Formula: C21H32O
Molecular Weight: 300.5
CAS: 432-60-0

Allylestrenol Description and Indication

Allylestrenol is an orally effective progesterone derivative with selective β- adrenergic action. It is generally prescribed to avoid pregnancy complications like threatened abortion, habitual abortion, threatened premature labour, failure of nidation, Metrorrhagia and premenstrual tension.

Allylestrenol has a powerful progestational effect, reducing myometrial activity and relaxing uterine hypertonic state. It also increases blood circulation, thereby improving maternal-placental function. Allylestrenol promotes the normal function of the placenta (including HCG production). The ingredient has no anti-ovulatory or androgenic properties.

The pharmacological actions of Allylestrenol are very similar to naturally occurring progesterone. It prepares the uterus for receiving the fertilized ovum and makes the endometrial lining thicker. Thus it supports implantation to sustain pregnancy. Uterine motility is suppressed by the action of Allylestrenol which helps in the maintenance of pregnancy.

Allylestrenol Mechanism of Action

There is often a fall in the level of placental hormones during premature termination of pregnancy. Allylestrenol stimulates the production and promotes the secretion of placental hormones (H.C.G, human placental lactogen, estrogens and progesterone) and oxytocinase in patients with pregnancies at risk.

Allylestrenol Contraindications

Allylestrenol is principally contraindicated in patients with renal or cardiac dysfunction, migraine, asthma, epilepsy, genital carcinoma, mammary carcinoma, abnormal vaginal bleeding, hepatic impairment or a history of herpes. In addition, care must be taken in case of allergic reactions to Allylestrenol or any of its ingredients.

Allylestrenol Adverse Drug Effects

Allylestrenol may cause gastro-intestinal disturbances, changes in appetite and/or weight.

Allylestrenol Drug Interactions

The optimal impact of Allylestrenol may be affected by drugs like:

Allylestrenol Formulation

Allylestrenol Brands

These are the following brands available for Allylestrenol: