Estradiol

Chemical Name:estra-1,3,5(10)-triene-3,17β-diol
Molecular Formula: C18H24O2
Molecular Weight: 272.39
CAS: 50-28-2

Estradiol Description and Indication

Estradiol is the most potent the group of endogenous estrogen steroids that includes Estrone and Estriol. Estradiol is responsible for growth of the breast and reproductive epithelia, maturation of long bones and development of secondary sexual characteristics in women. It is produced mainly by the ovaries, but also by adrenal glands. Estradiol levels are used to assess fertility, amenorrhea and precocious puberty in girls. Measurement of estrogen levels is also useful to monitor and titrate replacement therapy especially when the end points are long term health rather than the immediate relief of symptoms.

Estradiol is prescribed for the treatment of:

Estradiol Mechanism of Action

Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. It binds well to both estrogen receptors, ERα and ERβ, in contrast to certain other estrogens that preferentially act on either one of these receptors. Estradiol promotes growth and development of female reproductive system and secondary sexual characteristics and affects release of pituitary gonadotropin. It also inhibits ovulation and prevents postpartum breast engorgement.

Estradiol Contraindications

Estradiol is contraindicated in patients with the following conditions:

Estradiol Adverse Drug Effects

Estradiol Drug Interactions

The effects of Estradiol may be decreased by CYP1A2 and CYP3A4 inducers such as:

While when used with Estradiol, the effects of hydrocortisone and prednisolone may be enhanced.

Estradiol Formulations

Estradiol Brands

These are the following brands available for Estradiol:

  • Climaderm
  • Climara
  • Estrace
  • Estraderm
  • Estrofem
  • Estrogel
  • Kliogest
  • Vagifem