Dienogest 2 mg

Description and Indication

Dienogest is a nortestosterone derivative with no androgenic but rather an antiandrogenic activity of approximately one third of that of cyproterone acetate. Dienogest binds to the progesterone receptor of the human uterus with only 10% of the relative affinity of progesterone. Despite its low affinity to the progesterone receptor, dienogest has a strong progestogenic effect in vivo. Dienogest has no significant androgenic, mineralocorticoid or glucocorticoid activity in vivo.

Dienogest acts on endometriosis by reducing the endogenous production of oestradiol and thereby suppresses the trophic effects of estradiol on both the eutopic and ectopic endometrium. When given continuously, dienogest leads to a hypoestrogenic, hypergestagenic endocrine environment causing initial decidualization of endometrial tissue followed by atrophy of endometriotic lesions.

Storage

Store in a cool, dark and dry place.

Packaging Presentation

Dienogest Tablets 2 mg is supplied in a blister pack containing 14 tablets. Such two blisters are packed in an individual carton along with a package insert.

Each uncoated tablet contains:

Dienogest.....2 mg
Excipients.....Q.S.